Interprotomer Communication and Functional Asymmetry in H/ACA snoRNPs

Abstract excerpt

H/ACA small nucleolar ribonucleoproteins (H/ACA snoRNPs) facilitate essential cellular processes such as RNA modification, folding, and stability. Here, we present multiple cryo-EM structures of endogenous, catalytically active insect H/ACA snoRNPs containing two protomers assembled on a two-hairpin H/ACA snoRNA. By characterizing key protein-protein and protein-RNA interactions, we reveal the coordination of pseu...

Topics

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• Ribosomes
• RNA, Small Nucleolar
• Cryoelectron Microscopy
• Dyskeratosis Congenita
• Models, Molecular
• Mutation
• Nucleic Acid Conformation
• Ribonucleoproteins, Small Nucleolar

Identifiers and source

Literature Corpus work

ba6d8f70-ad44-593f-93c9-f7200f3cb717

DOI

10.1101/2025.06.07.658439