Article

Cryo-EM Structure of a Mammalian-specific Alternative Amyloid Exon

2022-08-24

Abstract excerpt

<h4>ABSTRACT</h4> hnRNPDL is a ribonucleoprotein (RNP) involved in transcription and RNA-processing, with missense mutations causing limb-girdle muscular dystrophy-3 (LGMDD3). Mammalian-specific alternative splicing (AS) renders three natural isoforms, hnRNPDL-2 being predominant in humans. We present the cryo-electron microscopy structure of full-length hnRNPDL-2 amyloid fibrils, which are stable, non-toxic, and...

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Literature Corpus work: 79a58c61-a4e1-50bc-956c-1f0c02bf5e93
DOI: 10.1101/2022.08.24.503855

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