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Article

Structural insights into human ELAC2 as a tRNA 3' processing enzyme.

Nucleic acids research - 27 Nov 2024

Xue Chenyang, Tian Junshan, Chen Yanhong, Liu Zhongmin

Abstract excerpt

Human elaC ribonuclease Z 2 (ELAC2) removes the 3' trailer of precursor transfer ribonucleic acid (pre-tRNA). Mutations in ELAC2 are highly associated with the development of prostate cancer and hypertrophic cardiomyopathy. However, the catalytic mechanism of ELAC2 remains unclear. We determined the cryogenic electron microscopy structures of human ELAC2 in various states, including the apo, pre-tRNA-bound and...

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Identifiers

PMID: 39494506
DOI: 10.1093/nar/gkae1014
PMCID: PMC11602120

Genes

ELAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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