Article

Distinct contributions of three GABAergic interneuron populations to a mouse model of Rett Syndrome

2017-06-25

Abstract excerpt

<h4>Background</h4> Rett Syndrome is a devastating neurodevelopmental disorder resulting from mutations in the gene MeCP2. MeCP2 is a transcriptional regulator active in many cell types throughout the brain. However, mutations of MeCP2 restricted to GABAergic cell types largely replicate the behavioral phenotypes associated with mouse models of Rett Syndrome, suggesting a key role for inhibitory interneurons in t...

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Literature Corpus work: 42044e43-d063-5047-9866-ac8ba3aca439
DOI: 10.1101/155382

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