Article

Loss of the MeCP2 gene in parvalbumin interneurons leads to an inhibitory deficit in the amygdala and affects its functional connectivity

2024-05-30

Abstract excerpt

<h4>Background</h4> MECP2 gene is located in the X-chromosome and encodes a methyl-CpG-binding protein involved in transcription regulation. The loss-of-function mutation of the MECP2 gene, leads to severe neurodevelopmental syndrome, Rett syndrome. Clinical picture of Rett syndrome includes, among other symptoms, social deficits and heightened anxiety. The amygdala is involved in the regulation of social behavi...

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Literature Corpus work: 93aa8347-eeaf-529a-8036-7de3242963b8
DOI: 10.1101/2024.05.30.596683

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