Article

Epigenetic clock acceleration is linked to age-at-onset of idiopathic and <i>LRRK2</i> Parkinson’s disease

2022-02-06

Abstract excerpt

Parkinson’s disease is a clinically and genetically heterogeneous movement disorder with highly variable age-at-onset. DNA methylation (DNAm) age is an epigenetic clock that could reflect biological aging. Studies of DNAm-age acceleration (difference between DNAm-age and chronological age) are pertinent to neurodegenerative diseases (e.g., Parkinson’s disease), for which aging is the strongest risk-factor. We asse...

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Literature Corpus work: 51114802-dd87-5851-a708-69643973603b
DOI: 10.1101/2022.02.04.22270486

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