Article

Epigenetic age acceleration in frontotemporal lobar degeneration: a comprehensive analysis in the blood and brain

2023-05-22

Abstract excerpt

Frontotemporal lobar degeneration (FTLD) includes a heterogeneous group of disorders pathologically characterized by the degeneration of the frontal and temporal lobes. In addition to major genetic contributors of FTLD such as mutations in MAPT, GRN , and C9orf72 , recent work has identified several epigenetic modifications including significant differential DNA methylation in DLX1 , and OTUD4 loci. As aging r...

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Literature Corpus work: 0a67058b-fba0-57ec-9dff-5731a49f82c7
DOI: 10.1101/2023.05.19.541419

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