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Article

Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum.

Nature communications - 2 Feb 2016

Lu Ake T, Hannon Eilis, Levine Morgan E, Hao Ke, Crimmins Eileen M, Lunnon Katie, Kozlenkov Alexey, Mill Jonathan, Dracheva Stella, Horvath Steve

Abstract excerpt

DNA methylation (DNAm) levels lend themselves for defining an epigenetic biomarker of aging known as the 'epigenetic clock'. Our genome-wide association study (GWAS) of cerebellar epigenetic age acceleration identifies five significant (P<5.0 × 10(-8)) SNPs in two loci: 2p22.1 (inside gene DHX57) and 16p13.3 near gene MLST8 (a subunit of mTOR complex 1 and 2). We find that the SNP in 16p13.3 has a cis-acting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26830004
DOI: 10.1038/ncomms10561
PMCID: PMC4740877

Genes

DHX57
MLST8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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