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Associations of epigenetic age acceleration with motor impairment: Evidence from the Parkinson's Progression Markers Initiative cohort.

Neurobiology of aging - 1 Aug 2026

Jiang Tao, Hui Julia, Feng Bowen, Tan Guojun, Yuan Guangwei, Yang Jingyun

Abstract excerpt

Motor decline is a hallmark of Parkinson's disease (PD) and biological aging, yet the specific relationship between systemic biological aging and neuromotor function remains under-characterized. This study leveraged longitudinal phenotypic and whole-blood DNA methylation data from the Parkinson's Progression Markers Initiative (PPMI) to evaluate associations between seven epigenetic aging measures, spanning...

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PMID: 41905169
DOI: 10.1016/j.neurobiolaging.2026.03.006

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