Back to search

Article

Associations of Epigenetic Age Acceleration with Motor Impairment: Evidence from the PPMI Cohort

2025-12-17

Abstract excerpt

<h4>Objective</h4> Motor decline is a hallmark of Parkinson’s disease (PD) and biological aging. While epigenetic clocks measure systemic biological aging, their specific relationship with neuromotor function in the context of aging and neurodegeneration remains under-characterized. This study utilized data from the Parkinson’s Progression Markers Initiative (PPMI) to examine the relationships between multiple DN...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c87dd6ff-b5e2-5aca-99e2-418087f9d5ff
DOI
10.64898/2025.12.16.25342400
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Associations of Epigenetic Age Acceleration with Motor Impairment: Evidence from the PPMI CohortDOI 10.64898/2025.12.16.25342400
Associations of epigenetic age acceleration with motor impairment: Evidence from the Parkinson's Progression Markers Initiative cohort.Semantic proximity
Epigenetic Clock Acceleration Is Linked to Age at Onset of Parkinson's Disease.Semantic proximity
Epigenetic clock acceleration is linked to age-at-onset of idiopathic and <i>LRRK2</i> Parkinson’s diseaseSemantic proximity
Epigenetic age acceleration in frontotemporal lobar degeneration: a comprehensive analysis in the blood and brainSemantic proximity
DNA Methylation Age Acceleration Is Not Associated with Age of Onset in Parkinson's DiseaseSemantic proximity
Epigenetic age acceleration and prevalent age- related neurological disorders: a two-sample Mendelian randomization studySemantic proximity
Epigenetic Age Acceleration in Frontotemporal Lobar Degeneration: A Comprehensive Analysis in the Blood and Brain.Semantic proximity
Properties of the epigenetic clock and age accelerationSemantic proximity
Epigenetic Clocks: In Aging-Related and Complex DiseasesSemantic proximity
Longitudinal Epigenome-Wide Methylation Study of Cognitive Decline and Motor Progression in Parkinson’s DiseaseSemantic proximity
Genome based subtyping identifies Parkinson’s disease subtypes with reproducible motor progression differences and clinical trial enrichment potentialSemantic proximity
DNA methylation age from peripheral blood predicts progression to Alzheimer’s disease, white matter disease burden, and cortical atrophySemantic proximity
Select a neighboring publication to make it the new centre.