Article

Properties of the epigenetic clock and age acceleration

2018-07-06

Abstract excerpt

<h4>Background</h4> The methylation status of numerous CpG sites in the human genome varies with age. The Horvath epigenetic clock used a wide variety of published DNA methylation data to produce an age prediction that has been widely used to, predict age in unknown samples, and draw conclusions about speed of ageing in various tissues, environments, and diseases. Despite its utility, there are a number of assump...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e968db27-25ca-562b-8493-5a422c46fcce
DOI: 10.1101/363143

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Properties of the epigenetic clock and age accelerationDOI 10.1101/363143Read

Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex.Semantic proximity Read

Recalibrating the Epigenetic Clock: Implications for Assessing Biological Age in the Human CortexSemantic proximity Read

DNA methylation age acceleration and risk factors for Alzheimer’s diseaseSemantic proximity Read

Current perspectives on the cellular and molecular features of epigenetic ageingSemantic proximity Read

Human epigenetic ageing is logarithmic with time across the entire lifespanSemantic proximity Read

Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's diseaseSemantic proximity Read

Insights into ageing rates comparison across tissues from recalibrating cerebellum DNA methylation clockSemantic proximity Read

Epigenetic Clocks: In Aging-Related and Complex DiseasesSemantic proximity Read

Aging the Brain: Multi-Region Methylation Principal Component Based Clock in the Context of Alzheimer’s DiseaseSemantic proximity Read

An epigenetic clock for chronological age estimation in East Asian populationsSemantic proximity Read

AltumAge: A Pan-Tissue DNA-Methylation Epigenetic Clock Based on Deep LearningSemantic proximity Read

Time is encoded by methylation changes at clustered CpG sitesSemantic proximity Read