Article
Identification of genetic modifiers of age-at-onset for familial Parkinson's disease.
Human molecular genetics - 1 Sept 2016
Hill-Burns Erin M, Ross Owen A, Wissemann William T, Soto-Ortolaza Alexandra I, Zareparsi Sepideh, Siuda Joanna, Lynch Timothy, Wszolek Zbigniew K, Silburn Peter A, Mellick George D, Ritz Beate, Scherzer Clemens R, Zabetian Cyrus P, Factor Stewart A, Breheny Patrick J, Payami Haydeh
Abstract excerpt
Parkinson's disease (PD) is the most common cause of neurodegenerative movement disorder and the second most common cause of dementia. Genes are thought to have a stronger effect on age-at-onset of PD than on risk, yet there has been a phenomenal success in identifying risk loci but not age-at-onset modifiers. We conducted a genome-wide study for age-at-onset. We analysed familial and non-familial PD separately,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.