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DNA methylation age acceleration is associated with ALS age of onset and survival

7 Mar 2020

Abstract excerpt

C9orf72-carriers and identical twins DNA methylation (DNAm) is a key epigenetic modification and linked to the risk of several neurodegenerative diseases (Supplementary introduction). The cumulative assessment of DNAm levels at age-related CpGs allows the estimation of multi-tissue DNAm age (epigenetic clock), which could be more accurate for assessing biological age than chronological age. Hypermethylation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32146547
DOI: 10.1007/s00401-020-02131-z

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