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Article

Epigenetic Clock Acceleration Is Linked to Age at Onset of Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Sept 2022

Tang Xuelin, Gonzalez-Latapi Paulina, Marras Connie, Visanji Naomi P, Yang Wanli, Sato Christine, Lang Anthony E, Rogaeva Ekaterina, Zhang Ming

Abstract excerpt

BACKGROUND: Aging is the strongest risk factor for Parkinson's disease (PD), which is a clinically heterogeneous movement disorder with highly variable age at onset. DNA methylation age (DNAm age) is an epigenetic clock that could reflect biological aging. OBJECTIVES: The aim was to evaluate whether PD age at onset is associated with DNAm-age acceleration (difference between DNAm age and chronological age)....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 35921480
DOI: 10.1002/mds.29157

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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