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Article

Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder

30 Mar 2023

Abstract excerpt

Isolated REM Sleep Behavior Disorder (iRBD) is the strongest prodromal marker for α-synucleinopathies. Overt α-synucleinopathies and aging share several mechanisms, but this relationship has been poorly investigated in prodromal phases. Using DNA methylation-based epigenetic clocks, we measured biological aging in videopolysomnography confirmed iRBD patients, videopolysomnography-negative and population-based...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36997543
DOI: 10.1038/s41531-023-00492-2

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