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Article

Anchoring high concentrations of SynGAP at postsynaptic densities via liquid-liquid phase separation.

Small GTPases - 1 Jul 2019

Zeng Menglong, Bai Guanhua, Zhang Mingjie

Abstract excerpt

SynGAP, encoded by SYNGAP1, is a Ras/Rap GTPase activator specifically expressed in the nervous systems. SynGAP is one of the most abundant proteins in the postsynaptic densities (PSDs) of excitatory synapses and acts as a critical synaptic activity brake by tuning down synaptic GTPase activities. Mutations of SYNGAP1 have been frequently linked to brain disorders including intellectual disability, autisms, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28524815
DOI: 10.1080/21541248.2017.1320350
PMCID: PMC6548289

Genes

PSD
SYNGAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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