Article

CDKL5 modulates structural plasticity of excitatory synapses via liquid-liquid phase separation

2025-03-17

Abstract excerpt

Activity-dependent synaptic remodeling, essential for neural circuit plasticity, is orchestrated by central organizers within the postsynaptic density (PSD), including the scaffolding protein PSD95. However, the molecular mechanisms driving this process remain incompletely understood. Here, we identify CDKL5, a protein associated with a severe neurodevelopmental condition known as CDKL5 deficiency disorder (CDD),...

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Literature Corpus work: 59b314e6-28b8-5cc0-a2a3-de1d50db9c94
DOI: 10.1101/2025.03.16.643581

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