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Article

Polymorphic HLA-C Receptors Balance the Functional Characteristics of KIR Haplotypes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2015

Hilton Hugo G, Guethlein Lisbeth A, Goyos Ana, Nemat-Gorgani Neda, Bushnell David A, Norman Paul J, Parham Peter

Abstract excerpt

The human killer cell Ig-like receptor (KIR) locus comprises two groups of KIR haplotypes, termed A and B. These are present in all human populations but with different relative frequencies, suggesting they have different functional properties that underlie their balancing selection. We studied the genomic organization and functional properties of the alleles of the inhibitory and activating HLA-C receptors...

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Identifiers

PMID: 26311903
DOI: 10.4049/jimmunol.1501358
PMCID: PMC4575877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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