Article
Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 1998
Winter C C, Gumperz J E, Parham P, Long E O, Wagtmann N
Abstract excerpt
Cytotoxicity of human NK cells is under negative control of killer cell Ig-like receptors (KIR) specific for HLA class I. To determine the specificity of five KIR containing two Ig domains (KIR2D), direct binding of soluble recombinant KIR2D to a panel of HLA class I transfectants was assayed. On...
Topics
- Alleles
- Amino Acid Substitution
- HLA-C Antigens
- Humans
- Killer Cells, Natural
- Mutagenesis, Site-Directed
- Phenylalanine
- Protein Binding
- Receptors, Immunologic
- Receptors, KIR
- Receptors, KIR2DL1
- Receptors, KIR2DL2
- Receptors, KIR2DL3
- Recombinant Fusion Proteins
- Solubility
- Transfection