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Article

Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 1998

Winter C C, Gumperz J E, Parham P, Long E O, Wagtmann N

Abstract excerpt

Cytotoxicity of human NK cells is under negative control of killer cell Ig-like receptors (KIR) specific for HLA class I. To determine the specificity of five KIR containing two Ig domains (KIR2D), direct binding of soluble recombinant KIR2D to a panel of HLA class I transfectants was assayed. One soluble KIR2D, derived from an inhibitory receptor with a long cytoplasmic tail (KIR2DL1), bound to HLA-C allotypes...

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PMID: 9670929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition.PMID 9670929Read ↗

Canonical and cross-reactive binding of NK cell inhibitory receptors to HLA-C allotypes is dictated by peptides bound to HLA-CSemantic proximity Read ↗

Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3.Semantic proximity Read ↗

KIR2DS1-mediated activation overrides NKG2A-mediated inhibition in HLA-C C2-negative individuals.Semantic proximity Read ↗

Innate receptors with high specificity for HLA class I–peptide complexesSemantic proximity Read ↗

KIR2DL4 is an IL-2-regulated NK cell receptor that exhibits limited expression in humans but triggers strong IFN-gamma production.Semantic proximity Read ↗

Polymorphic HLA-C Receptors Balance the Functional Characteristics of KIR Haplotypes.Semantic proximity Read ↗

Uptake of CCR7 by KIR2DS4 + NK Cells Is Induced upon Recognition of Certain HLA-C AllelesSemantic proximity Read ↗

HLA-Cw*0102-restricted HIV-1 p24 epitope variants can modulate the binding of the inhibitory KIR2DL2 receptor and primary NK cell function.Semantic proximity Read ↗

Mutation at positively selected positions in the binding site for HLA-C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3.Semantic proximity Read ↗

Human KIR2DL5 is an inhibitory receptor expressed on the surface of NK and T lymphocyte subsets.Semantic proximity Read ↗

Allelic variation in KIR2DL3 generates a KIR2DL2-like receptor with increased binding to its HLA-C ligand.Semantic proximity Read ↗

The Activating Human NK Cell Receptor KIR2DS2 Recognizes a β2-Microglobulin–Independent Ligand on Cancer CellsSemantic proximity Read ↗

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