Article
Large spectrum of HLA-C recognition by killer Ig-like receptor (KIR)2DL2 and KIR2DL3 and restricted C1 SPECIFICITY of KIR2DS2: dominant impact of KIR2DL2/KIR2DS2 on KIR2D NK cell repertoire formation.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2013
David Gaëlle, Djaoud Zakia, Willem Catherine, Legrand Nolwenn, Rettman Pauline, Gagne Katia, Cesbron Anne, Retière Christelle
Abstract excerpt
The interactions of killer Ig-like receptor 2D (KIR2D) with HLA-C ligands contribute to functional NK cell education and regulate NK cell functions. Although simple alloreactive rules have been established for inhibitory KIR2DL, those governing activating KIR2DS function are still undefined, and those governing the formation of the KIR2D repertoire are still debated. In this study, we investigated the specificity...
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