Article

The influence of HLA-C and KIR on natural killer cell function

2016-01-01

Abstract excerpt

Natural killer (NK) cells are innate cytotoxic lymphocytes with important roles in immunity and pregnancy. The NK cell inhibitory receptor KIR2DL3 binds HLA-C1 (HLA-C alleles bearing Asn80) while KIR2DL1 binds HLA-C2 (Lys80). KIR2DL3 and HLA-C1 homozygous individuals are protected from chronic viral infection while mothers carrying KIR2DL1 with HLA-C2 positive foetuses are at a higher risk of pregnancy disorders....

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Literature Corpus work: 0224edf9-c4f3-536d-bfb8-83e822cb58a9
DOI: 10.25560/57025

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