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Article

KIR2DS1-mediated activation overrides NKG2A-mediated inhibition in HLA-C C2-negative individuals.

International immunology - 1 Apr 2008

Foley Bree, De Santis Dianne, Lathbury Louise, Christiansen Frank, Witt Campbell

Abstract excerpt

NK cell cytotoxicity is controlled through a balance of both activating and inhibitory signals. The HLA specificity of alloreactive NK cells has been previously shown to be controlled by inhibitory killer immunoglobulin-like receptors (KIRs). Alloreactive NK cells lyse targets that lack the HLA ligand for their inhibitory KIR. We have characterized in detail an alloreactive NK clone in which the specificity is...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18308713
DOI: 10.1093/intimm/dxn013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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