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Article

Sequence variations in HIV-1 p24 Gag-derived epitopes can alter binding of KIR2DL2 to HLA-C*03:04 and modulate primary natural killer cell function.

AIDS (London, England) - 19 Jun 2014

van Teijlingen Nienke H, Hölzemer Angelique, Körner Christian, García-Beltrán Wilfredo F, Schafer Jamie L, Fadda Lena, Suscovich Todd J, Brander Christian, Carrington Mary, Evans David T, van Baarle Debbie, Altfeld Marcus

Abstract excerpt

OBJECTIVE: The aim of this study was to assess the consequence of sequence variations in HLA-C03:04-presented HIV-1 p24 Gag epitopes on binding of the inhibitory natural killer (NK) cell receptor KIR2DL2 to HLA-C03:04. DESIGN: HIV-1 may possibly evade recognition by KIR+ NK cells through selection of sequence variants that interfere with the interactions of inhibitory killer cell immunoglobulin-like receptors...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24785948
DOI: 10.1097/QAD.0000000000000284
PMCID: PMC4453925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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