Article
HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells.
Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 1993
Colonna M, Borsellino G, Falco M, Ferrara G B, Strominger J L
Abstract excerpt
Natural killer (NK) cells recognize alloantigens on normal cells. One of these alloantigens correlates with homozygosity for a dimorphism of HLA-C at positions 77-80, which is shared by a number of HLA-C alleles. A second allelic alloantigen correlates with homozygosity for the alternative HLA-C...
Topics
- Alleles
- Amino Acid Sequence
- Asparagine
- B-Lymphocytes
- Cell Line
- Cell Line, Transformed
- Cytotoxicity, Immunologic
- Gene Deletion
- Genes, MHC Class I
- HLA-C Antigens
- Herpesvirus 4, Human
- Homozygote
- Humans
- Isoantigens
- Killer Cells, Natural