Article

Multi-Step Hsp70 Recruitment by Class B J-Domain Proteins Drives Efficient Protein Disaggregation

2026-02-09

Abstract excerpt

Protein disaggregation by the Hsp70 system is essential for maintaining cellular proteostasis, especially under stress and proteotoxic diseases. J-Domain Proteins (JDPs) assist and regulate Hsp70 by stimulating substrate binding and ATP hydrolysis through their signature J-domain. In Class B JDPs, which play a key role in disaggregation of amyloids and amorphous aggregates, the J-domain is autoinhibited and requir...

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Literature Corpus work: 0863a905-3d14-58e5-8e17-3c3bdde4a679
DOI: 10.64898/2026.02.06.704373

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