Article

Chromatin and transcriptional response to loss of TBX1 in early differentiation of mouse cells

2020-06-06

Abstract excerpt

<h4>ABSTRACT</h4> The T-box transcription factor TBX1 has critical roles in the cardiopharyngeal lineage and the gene is haploinsufficient in DiGeorge syndrome, a typical developmental anomaly of the pharyngeal apparatus. Despite almost two decades of research, if and how TBX1 function triggers chromatin remodeling is not known. Here, we explored genome-wide gene expression and chromatin remodeling in two indepen...

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Literature Corpus work: 5090de89-cc20-5d6d-bee6-01577fa2d029
DOI: 10.1101/2020.06.06.137026

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