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Article

Manipulation of endogenous regulatory elements and transgenic analyses of the Tbx1 gene.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2010

Zhang Zhen, Baldini Antonio

Abstract excerpt

Pharyngeal morphogenesis is a complex process involving precise coordination of multiple cell types and transcription networks. TBX1 heterozygous mutation causes DiGeorge Syndrome, a typical disorder of pharyngeal development. In mice, loss of function of Tbx1 causes severe disruption of pharyngeal development. Therefore, to understand the regulatory circuits controlling the pharyngeal apparatus, it is important...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Developmental

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Source

Identifiers

PMID: 21107579
DOI: 10.1007/s00335-010-9304-4

Genes

TBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Manipulation of endogenous regulatory elements and transgenic analyses of the Tbx1 gene.PMID 21107579Read ↗

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Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion.Semantic proximity Read ↗

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