Article

Dose-dependent sensitivity of human 3D chromatin to a heart disease-linked transcription factor

2025-01-12

Abstract excerpt

Dosage-sensitive transcription factors (TFs) underlie altered gene regulation in human developmental disorders, and cell-type specific gene regulation is linked to the reorganization of 3D chromatin during cellular differentiation. Here, we show dose-dependent regulation of chromatin organization by the congenital heart disease (CHD)- linked, lineage-restricted TF TBX5 in human cardiomyocyte differentiation. Genom...

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Identifiers and source

Literature Corpus work: 9972aee1-a292-59fa-847d-f1ba27331591
DOI: 10.1101/2025.01.09.632202

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