Article
Transrepression activity of T-box1 in a gene regulation network in mouse cells.
Gene - 1 Dec 2012
Yee Karen K L, Yagi Hisato, Matsuoka Rumiko, Nakanishi Toshio, Furukawa Toru
Abstract excerpt
T-box1 (TBX1) has been identified as a candidate disease-causing gene in DiGeorge syndrome/conotruncal anomaly face syndrome (DGS/CAFS). Tbx1 can function as a transcriptional transactivator as well as a transrepressor. Although the transactivating role of Tbx1 has been the focus of a number of published studies, its transrepression activity has been largely unexplored. Thus, this study centers on the...
Topics
- 14-3-3 Proteins
- Animals
- Cell Line, Tumor
- Gene Dosage
- Gene Knockdown Techniques
- Gene Regulatory Networks
- Humans
- Hyaluronan Receptors
- Mice
- Mitochondrial Proteins
- Mutation
- RNA, Small Interfering
- T-Box Domain Proteins