Article
Transrepression activity of T-box1 in a gene regulation network in mouse cells.
Gene - 1 Dec 2012
Yee Karen K L, Yagi Hisato, Matsuoka Rumiko, Nakanishi Toshio, Furukawa Toru
Abstract excerpt
T-box1 (TBX1) has been identified as a candidate disease-causing gene in DiGeorge syndrome/conotruncal anomaly face syndrome (DGS/CAFS). Tbx1 can function as a transcriptional transactivator as well as a transrepressor. Although the transactivating role of Tbx1 has been the focus of a number of published studies, its transrepression activity has been largely unexplored. Thus, this study centers on the...
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