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Article

Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication

4 Apr 2014

Abstract excerpt

Velo-cardio-facial/DiGeorge syndrome, also known as 22q11.2 deletion syndrome, is a congenital anomaly disorder characterized by craniofacial anomalies including velo-pharyngeal insufficiency, facial muscle hypotonia and feeding difficulties, in part due to hypoplasia of the branchiomeric muscles. Inactivation of both alleles of mouse Tbx1, encoding a T-box transcription factor, deleted on chromosome 22q11.2,...

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Identifiers

PMID: 24705356
DOI: 10.1093/hmg/ddu140

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of masticationPMID 24705356Read ↗

The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesis.Semantic proximity Read ↗

Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations.Semantic proximity Read ↗

Identification of a Tbx1/Tbx2/Tbx3 genetic pathway governing pharyngeal and arterial pole morphogenesis.Semantic proximity Read ↗

22q11 deletion syndrome: a role for TBX1 in pharyngeal and cardiovascular development.Semantic proximity Read ↗

Single cell transcriptomics uncovers a non-autonomous <i>Tbx1</i> -dependent genetic program controlling cardiac neural crest cell deployment and progressionSemantic proximity Read ↗

Single cell multi-omic analysis identifies a <i>Tbx1</i> -dependent multilineage primed population in the murine cardiopharyngeal mesodermSemantic proximity Read ↗

Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field.Semantic proximity Read ↗

Reduced dosage of β-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndromeSemantic proximity Read ↗

Understanding the role of Tbx1 as a candidate gene for 22q11.2 deletion syndrome.Semantic proximity Read ↗

Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion.Semantic proximity Read ↗

<i>Tbx1</i> Regulates Proliferation and Differentiation of Multipotent Heart ProgenitorsSemantic proximity Read ↗

Regulatory mutants of the <i>Tbx1</i> gene alter transcription programs of lineage determination and patterning in early mesodermSemantic proximity Read ↗

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