Article

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells

2018-05-31

Abstract excerpt

<h4>ABSTRACT</h4> The epigenetic regulator TET2 is frequently mutated in hematological diseases. Mutations have been shown to arise in hematopoietic stem cells early in disease development, lead to altered DNA methylation landscapes and to an increased risk of hematopoietic malignancy. Here, we show by genome-wide mapping of TET2 binding sites in different cell types that TET2 localizes to regions of open chroma...

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Literature Corpus work: 302b290a-ba9c-5360-b20b-39d6e627698c
DOI: 10.1101/336008

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