Article

Regulatory mutants of the <i>Tbx1</i> gene alter transcription programs of lineage determination and patterning in early mesoderm

2026-08-10

Abstract excerpt

<h4>ABSTRACT</h4> The Tbx1 gene is haploinsufficient in mice and in humans, where it causes a DiGeorge syndrome phenotype characterized by developmental deficits of the pharyngeal apparatus. TBX1 plays a critical role in the differentiation and regionalization of the cardiopharyngeal mesoderm lineage and its derivatives. Nevertheless, its regulation is incompletely understood. Here we used a combination of compu...

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Literature Corpus work: 60b0a1fc-e694-57f5-abf6-74052d8cdd95
DOI: 10.64898/2026.08.08.743664

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