Back to search

Article

Profiling colon cancer architecture with spatial transcriptomics identifies clinically relevant stromal ecotypes

2026-02-27

Abstract excerpt

<title>Abstract</title> <p>Despite advances in characterizing intra-tumor heterogeneity in colon cancer (CC), its spatial organization remains to be fully delineated. We generated a large spatial transcriptomic atlas of 48 stage III CC and identified recurrent, biologically relevant spatial ecosystems. Recurrence-associated analysis revealed stromal-specific upregulation of a set of genes including the regenerati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
504ed572-5e66-581d-81d1-a70e70a27bda
DOI
10.21203/rs.3.rs-8583137/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Profiling colon cancer architecture with spatial transcriptomics identifies clinically relevant stromal ecotypesDOI 10.21203/rs.3.rs-8583137/v1
CD44+ cells enhance pro-tumor stroma in the spatial landscape of colorectal cancer leading edgeSemantic proximity
Integrating spatial and single-cell transcriptomics reveals tumor heterogeneity and intercellular networks in colorectal cancerSemantic proximity
High-definition spatial transcriptomic profiling of immune cell populations in colorectal cancerSemantic proximity
Spatial Transcriptomics Reveals Stromal-Partitioned Growth in Primary Colorectal Cancer and Host-Permeated Architecture in Liver MetastasesSemantic proximity
Spatial tumour gene signature discriminates neoplastic from non-neoplastic compartments in colon cancer: unravelling predictive biomarkers for relapseSemantic proximity
Single-cell and spatial transcriptomics define a C3-centred multicellular ecology in colorectal liver metastasisSemantic proximity
Spatial transcriptomics atlas reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment components in colorectal cancerSemantic proximity
High-resolution integrative analysis allows characterization and spatial annotation of normal and cancer-associated colon fibroblastsSemantic proximity
Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomicsSemantic proximity
Charting the Heterogeneity of Colorectal Cancer Consensus Molecular Subtypes using Spatial TranscriptomicsSemantic proximity
A spatial stromal–vascular barrier niche links tumor architecture to immune remodeling and clinicopathologic statesSemantic proximity
Integrating spatial and single-cell transcriptomics reveals tumor heterogeneity and intercellular networks in colorectal cancerSemantic proximity
Select a neighboring publication to make it the new centre.