Back to search

Article

A spatial stromal–vascular barrier niche links tumor architecture to immune remodeling and clinicopathologic states

2026-06-05

Abstract excerpt

<title>Abstract</title> <p>Purpose Immune-cell abundance does not necessarily indicate immune access to malignant epithelial compartments in colorectal cancer (CRC). We developed an image-derived stromal–vascular barrier score to quantify spatial tissue architecture and evaluate its immune, clinicopathologic, cross-cancer, and cross-modal relevance. Methods and Materials Multiplex image-derived cellular and spati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3825cf48-f7fa-5e07-8c5e-bded4014d4d5
DOI
10.21203/rs.3.rs-9739369/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A spatial stromal–vascular barrier niche links tumor architecture to immune remodeling and clinicopathologic statesDOI 10.21203/rs.3.rs-9739369/v1
Revisiting the immune microenvironment of human colorectal cancer in the era of single-cell and spatial omicsSemantic proximity
Spatial Transcriptomics Reveals Stromal-Partitioned Growth in Primary Colorectal Cancer and Host-Permeated Architecture in Liver MetastasesSemantic proximity
INSIGHT: Spatially resolved survival modelling from routine histology crosslinked with molecular profiling reveals prognostic epithelial-immune axes in stage II/III colorectal cancerSemantic proximity
Spatial Topology Reveals Biologically Distinct Recurrent Motifs in Colorectal CancerSemantic proximity
High-definition spatial transcriptomic profiling of immune cell populations in colorectal cancerSemantic proximity
Spatially Resolved Transcriptomics Deconvolutes Histological Prognostic Subgroups in Patients with Colorectal Cancer and Synchronous Liver MetastasesSemantic proximity
Spatial Dynamics Links PD-L1 and Tumor-Associated Macrophage–Enriched Niches to Immune and Mesenchymal States in Microsatellite Stable Colorectal CancerSemantic proximity
Identification of Distinct Immune Subtypes in Colorectal Cancer Based on the Stromal CompartmentSemantic proximity
Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive FrontSemantic proximity
Comprehensive characterization of tumor microenvironment in colorectal cancer via histopathology-molecular analysisSemantic proximity
Spatially resolved C1QC+ macrophage-CD4+ T cell niche in colorectal cancer microenvironment: implications for immunotherapy responseSemantic proximity
High-Resolution Spatial Proteomics Characterises Colorectal Cancer Consensus Molecular SubtypesSemantic proximity
Select a neighboring publication to make it the new centre.