Article

Integrating spatial and single-cell transcriptomics reveals tumor heterogeneity and intercellular networks in colorectal cancer

2024-01-10

Abstract excerpt

<title>Abstract</title> <p>Single cell RNA sequencing (scRNA-seq), a powerful tool for studying the tumor microenvironment (TME), does not preserve/provide spatial information on tissue morphology and cellular interactions. To understand the crosstalk between diverse cellular components in proximity in the TME, we performed scRNA-seq coupled with spatial transcriptomic (ST) assay to profile 41,700 cells from thre...

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Literature Corpus work: 48ce01ab-3d4d-5233-9b70-a2382678e175
DOI: 10.21203/rs.3.rs-3820516/v1

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