Article

Charting the Heterogeneity of Colorectal Cancer Consensus Molecular Subtypes using Spatial Transcriptomics

2023-01-23

Abstract excerpt

The heterogeneity of colorectal cancer (CRC) contributes to substantial differences in patient response to standard therapies. The consensus molecular subtypes (CMS) of CRC is the most widely-used gene expression-based classification and has contributed to a better understanding of disease heterogeneity and prognosis. Nevertheless, CMS intratumoral heterogeneity restricts its clinical application, stressing the ne...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4824a11a-bc5f-5eab-b92a-28a4d14b4434
DOI: 10.1101/2023.01.23.525135

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Charting the Heterogeneity of Colorectal Cancer Consensus Molecular Subtypes using Spatial TranscriptomicsDOI 10.1101/2023.01.23.525135Read

High-Resolution Spatial Proteomics Characterises Colorectal Cancer Consensus Molecular SubtypesSemantic proximity Read

Single-cell and spatial transcriptomic analysis reveals tumor cell heterogeneity and underlying molecular program in colorectal cancerSemantic proximity Read

Revisiting the immune microenvironment of human colorectal cancer in the era of single-cell and spatial omicsSemantic proximity Read

Spatial transcriptomics and scRNA-seq: decoding tumor complexity and constructing prognostic models in colorectal cancerSemantic proximity Read

Integrating spatial and single-cell transcriptomics reveals tumor heterogeneity and intercellular networks in colorectal cancerSemantic proximity Read

Integrating spatial and single-cell transcriptomics reveals tumor heterogeneity and intercellular networks in colorectal cancerSemantic proximity Read

Spatial and single‐cell transcriptomic analysis reveals fibroblasts dependent immune environment in colorectal cancerSemantic proximity Read

Understanding the cellular and molecular heterogeneity in colorectal cancer through the use of single-cell RNA sequencingSemantic proximity Read

Intratumoral Heterogeneity of CRC Revealed by Single-Cell Transcriptome Analysis, which Results in Poor Prognosis Clinical OutcomesSemantic proximity Read

Single-Cell Transcriptome Analysis Reveals Heterogeneity and Convergence of the Tumor Microenvironment in CRCSemantic proximity Read

Dissection and reconstruction of the colorectal cancer tumor microenvironmentSemantic proximity Read

Redefining colorectal cancer classification and clinical stratification through a single-cell atlasSemantic proximity Read