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CD44+ cells enhance pro-tumor stroma in the spatial landscape of colorectal cancer leading edge

12 Mar 2025

Abstract excerpt

Abstract Background The heterogeneity of tumors significantly impacts on colorectal cancer (CRC) progression. However, the influence of this heterogeneity on the spatial architecture of CRC remains largely unknown. Methods Spatial transcriptomic (ST) analysis of AOM/DSS-induced colorectal cancer (CRC), integrated with single-cell RNA sequencing, generated a comprehensive spatial atlas of CRC. Pseudotime...

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PMID: 40069574
DOI: 10.1038/s41416-025-02968-9

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