Article

Chromatin Accessibility Shapes Developmental-Specific Lineage Plasticity in Hematopoiesis

2025-12-04

Abstract excerpt

Cell differentiation is governed by dynamic changes in chromatin accessibility, and its dysregulation underlies multiple disease states. Prior to birth, development of the hematopoietic system constitutes a period of broad differentiation potential, with certain immune cells arising exclusively during ontogeny. While age is known to affect lineage bias, the underlying molecular differences driving lineage preferen...

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Literature Corpus work: 4fddd528-1fbf-56a4-ace6-95f2d6aeab8c
DOI: 10.64898/2025.12.02.691283

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