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Article

Chromatin accessibility landscape of pediatric T‐lymphoblastic leukemia and human T‐cell precursors

5 Aug 2020

Abstract excerpt

We aimed at identifying the developmental stage at which leukemic cells of pediatric T-ALLs are arrested and at defining leukemogenic mechanisms based on ATAC-Seq. Chromatin accessibility maps of seven developmental stages of human healthy T cells revealed progressive chromatin condensation during T-cell maturation. Developmental stages were distinguished by 2,823 signature chromatin regions with 95% accuracy....

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PMID: 32755029
DOI: 10.15252/emmm.202012104

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