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Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution

3 Sept 2020

Abstract excerpt

Proper development of fetal germ cells (FGCs) is vital for the precise transmission of genetic and epigenetic information through generations. The transcriptional landscapes of human FGC development have been revealed; however, the epigenetic reprogramming process of FGCs remains elusive. Here, we profiled the genome-wide DNA methylation and chromatin accessibility of human FGCs at different phases as well as...

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PMID: 32884136
DOI: 10.1038/s41422-020-00401-9

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