Article

Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance

2020-08-24

Abstract excerpt

<title>Abstract</title> <p>Fibrosis is a hallmark of adipose tissue (AT) dysfunction and obesity-associated insulin resistance that results from an impaired collagen turnover. Peptidase D (PEPD) plays a vital role in collagen turnover by degrading proline-containing dipeptides. Nevertheless, its specific function and importance in AT is unknown. GWAS identified the rs731839 variant in the locus near PEPD that unc...

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Literature Corpus work: 4fdb2b91-e2dd-5d57-9e72-7bf54353d972
DOI: 10.21203/rs.3.rs-57182/v1

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