Article

Cyclophilin D Deficiency Exacerbates Diet-Induced Obesity and Selectively Enhances Skeletal Muscle Mitochondrial Respiration in Mice

2026-05-04

Abstract excerpt

<title>Abstract</title> <p> Mitochondrial dysfunction is a hallmark of obesity-associated metabolic disease, with the mitochondrial permeability transition pore serving as a key regulator of cellular energy homeostasis. Cyclophilin D, encoded by <italic>Ppif</italic> , is the principal regulatory component of this pore and has been implicated in insulin secretion, adipocyte survival, and whole-body energy bala...

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Literature Corpus work: 0b805028-22a0-5d37-8cc6-8c9bd171026e
DOI: 10.21203/rs.3.rs-9472657/v1

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Cyclophilin D Deficiency Exacerbates Diet-Induced Obesity and Selectively Enhances Skeletal Muscle Mitochondrial Respiration in MiceDOI 10.21203/rs.3.rs-9472657/v1Read

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