Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy.

doi:10.1158/2159-8290.CD-15-1177

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Article

Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy.

Cancer discovery - 1 Aug 2016

Incio Joao, Liu Hao, Suboj Priya, Chin Shan M, Chen Ivy X, Pinter Matthias, Ng Mei R, Nia Hadi T, Grahovac Jelena, Kao Shannon, Babykutty Suboj, Huang Yuhui, Jung Keehoon, Rahbari Nuh N, Han Xiaoxing, Chauhan Vikash P, Martin John D, Kahn Julia, Huang Peigen, Desphande Vikram, Michaelson James, Michelakos Theodoros P, Ferrone Cristina R, Soares Raquel, Boucher Yves, Fukumura Dai, Jain Rakesh K

Abstract excerpt

UNLABELLED: It remains unclear how obesity worsens treatment outcomes in patients with pancreatic ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes inflammation and fibrosis. We found in mouse models of PDAC that obesity also promotes desmoplasia associated with accelerated tumor growth and impaired delivery/efficacy of chemotherapeutics through reduced perfusion. Genetic and pharmacologic...

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Identifiers

PMID: 27246539
DOI: 10.1158/2159-8290.CD-15-1177
PMCID: PMC4972679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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