Article
Prostaglandin E2-EP4 Axis Promotes Lipolysis and Fibrosis in Adipose Tissue Leading to Ectopic Fat Deposition and Insulin Resistance.
Cell reports - 13 Oct 2020
Inazumi Tomoaki, Yamada Kiyotaka, Shirata Naritoshi, Sato Hiroyasu, Taketomi Yoshitaka, Morita Kazunori, Hohjoh Hirofumi, Tsuchiya Soken, Oniki Kentaro, Watanabe Takehisa, Sasaki Yutaka, Oike Yuichi, Ogata Yasuhiro, Saruwatari Junji, Murakami Makoto, Sugimoto Yukihiko
Abstract excerpt
Lipolysis, the breakdown of triglyceride storage in white adipose tissue, supplies fatty acids to other tissues as a fuel under fasting conditions. In morbid obesity, fibrosis limits adipocyte expandability, resulting in enforced lipolysis, ectopic fat distribution, and ultimately insulin resistance. Although basal levels of lipolysis persist even after feeding, the regulatory mechanisms of basal lipolysis remain...
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