Article

Fibroblast activation protein enzyme deficiency prevents liver steatosis, insulin resistance and glucose intolerance and increases fibroblast growth factor-21 in diet induced obese mice

2018-11-04

Abstract excerpt

<h4>Background & Aims</h4> Fibroblast activation protein-a (FAP) is a post-proline peptidase closely related to dipeptidyl peptidase-4. FAP degrades bioactive peptides including fibroblast growth factor-21 (FGF-21) and neuropeptide Y. We examined metabolic outcomes of specific genetic ablation of FAP and its enzyme activity in a mouse model of diet-induced obesity (DIO) causing fatty liver. <h4>Methods</h4> Wild...

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Literature Corpus work: 7fee02dc-5180-573b-9d12-8b762c07c486
DOI: 10.1101/460279

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