Article

MyD88 Inhibition Ameliorates Diabetes-Induced Hepatic Inflammation and Gluconeogenesis Through Adipose IL-10 Induction

2026-02-25

Abstract excerpt

<h4>Background: </h4> Myeloid differentiation factor 88 (MyD88) signaling plays a central role in inflammatory pathway activation. Adipose-derived interleukin-10 (IL-10), which is induced by insulin and lipopolysaccharides, suppresses hepatic glucose production. This study investigated the role of MyD88/IL-10 signaling in diabetes-induced systemic inflammation and hepatic gluconeogenesis. <h4>Methods:</h4> Stromal...

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Literature Corpus work: a6470318-0cd1-5853-b77c-17b04b00eab0
DOI: 10.20944/preprints202602.1384.v1

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