Article

Adipocyte lipolysis abrogates skin fibrosis in a Wnt/DPP4-dependent manner

2021-01-21

Abstract excerpt

Tissue fibrosis in many organs results from altered and excessive extracellular matrix (ECM) protein deposition 1 . Concomitant with ECM expansion, resident lipid-filled cells including mature adipocytes are lost in human and mouse fibrosis 2-5 , yet the mechanisms that drive mature adipocyte lipid loss and their contribution to tissue fibrosis are unknown. Here, we identify an early, fibro-protective role of ma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7e79069b-c1d1-5a77-a99b-81de3e6df814
DOI: 10.1101/2021.01.21.427497

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Adipocyte lipolysis abrogates skin fibrosis in a Wnt/DPP4-dependent mannerDOI 10.1101/2021.01.21.427497Read

Lipodystrophy and recovery are mediated by the Wnt/lipogenesis axis during skin fibrosisSemantic proximity Read

Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regenerationSemantic proximity Read

Mast-cell driven dermal white adipose tissue remodeling amplifies inflammation and fibrosis in atopic dermatitisSemantic proximity Read

Dermal adipogenesis protects against neutrophilic skin inflammationSemantic proximity Read

Selective deletion of PPARβ/δ in fibroblasts causes dermal fibrosis by attenuated LRG1 expressionSemantic proximity Read

A lipase-independent pathway of lipid release and immune modulation by adipocytesSemantic proximity Read

Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse SkinSemantic proximity Read

Evaluation of human dermal fibroblasts directly reprogrammed to adipocyte-like cells as a metabolic disease model.Semantic proximity Read

JAK/STAT inhibitor therapy partially rescues the lipodystrophic autoimmune phenotype in Clec16a KO mice.Semantic proximity Read

Adipogenic role of alternatively activated macrophages in β-adrenergic remodeling of white adipose tissue.Semantic proximity Read

Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistanceSemantic proximity Read

The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis.Semantic proximity Read