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Article

Modelling schizophrenia using human induced pluripotent stem cells.

Nature - 12 May 2011

Brennand Kristen J, Simone Anthony, Jou Jessica, Gelboin-Burkhart Chelsea, Tran Ngoc, Sangar Sarah, Li Yan, Mu Yangling, Chen Gong, Yu Diana, McCarthy Shane, Sebat Jonathan, Gage Fred H

Abstract excerpt

Schizophrenia (SCZD) is a debilitating neurological disorder with a world-wide prevalence of 1%; there is a strong genetic component, with an estimated heritability of 80-85%. Although post-mortem studies have revealed reduced brain volume, cell size, spine density and abnormal neural distribution in the prefrontal cortex and hippocampus of SCZD brain tissue and neuropharmacological studies have implicated...

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PMID: 21490598
DOI: 10.1038/nature09915
PMCID: PMC3392969

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