Article

RETSAT associates with DDX39B to promote fork restarting and resistance to gemcitabine based chemotherapy in pancreatic ductal adenocarcinoma

2022-07-08

Abstract excerpt

<title>Abstract</title> <p>Background: Severe hypoxia is a prominent character of pancreatic ductal adenocarcinoma (PDAC) microenvironment. In the process of gemcitabine based chemotherapy, PDAC cells are insulted from replication stresses co-induced by hypoxia and gemcitabine. However, PDAC cells get outstanding abilities to resist to such harsh conditions and keep proliferating, causing a major obstacle for cu...

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Literature Corpus work: 4fc94459-37f9-551c-8351-82c17bf25d94
DOI: 10.21203/rs.3.rs-1799713/v1

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