Article

PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress

2018-06-02

Abstract excerpt

<h4>ABSTRACT</h4> During carcinogenesis, cells are exposed to increased replication stress due to replication fork arrest at sites of DNA lesions and other difficult to replicate regions. Efficient fork restart and DNA repair are important for cancer cell proliferation. We previously showed that the ADP-ribosyltransferase PARP10 interacts with the replication protein PCNA and promotes lesion bypass by recruiting...

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Literature Corpus work: e0857d57-e3bb-5d39-b422-8ffec1049036
DOI: 10.1101/337220

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